Lozowick attended art school in Kiev for two years. In 1906 he moved to New York with his family, and in 1912 he entered the school of the National Academy of Design where he studied with Leon Kroll and Emil Carlsen. He subsequently graduated Phi Beta Kappa from Ohio State University and joined the army in 1918. In Berlin in 1920 he became friends with Laszlo Moholy-Nagy, El Lissitsky, and the avant-garde Russian artists affiliated with the November-gruppe. On his return to New York in 1924 he joined the executive board of the New Masses and exhibited his machine drawings in the 1926 exhibition of Katherine Dreier's Société Anonyme. A member of the American Artists Congress, Lozowick treated socially relevant themes during the 1930s, although he is particularly known for his geometrically formulated lithographs of urban cityscapes. In his later work a romantic impulse occasionally surfaces.